The table below contains all Orthologs. For more information about the gene, please click on the gene name.


Pathways Homo sapiens Mus musculus Caenorhabditis elegans Drosophila melanogaster Arabdopsis thaliana Saccharomyces cerevisiae Schizosaccharomyces pombe
Base Excision Repair (BER) APEX1 Ape1 R09B3.1a Rrp1 ARP APN2 apn2
Base Excision Repair (BER) APEX2 Apex2 ApII
Base Excision Repair (BER) LIG3 Lig3 C29A12.3 CG17227 CDC9 adl1
Base Excision Repair (BER) MBD4 Mbd4 MBD4
Base Excision Repair (BER) MPG Mpg MAG1 mag1
Base Excision Repair (BER) MUTYH (MYH) Mutyh R10E4.5 CG9272 MYH-related myh
Base Excision Repair (BER) NEIL1 Neil1
Base Excision Repair (BER) NEIL2 Neil2
Base Excision Repair (BER) NEIL3 Neil3 Y56A3A.27 Top3a AT5G13920
Base Excision Repair (BER) NTHL1 (NTH1) Nthl1 R10E4.5 CG9272 AT2G31450 NTG1 mag1
Base Excision Repair (BER) OGG1 Ogg1 Ogg1 OGG1 OGG1
Base Excision Repair (BER) PARG Parg H23L24.5 pme-4
Base Excision Repair (BER) PARP1 (ADPRT) Parp1 Y71F9AL.18 Parp PARP
Base Excision Repair (BER) PARP2 (ADPRTL2) Parp2 Y71F9AL.18 Parp PARP
Base Excision Repair (BER) PNKP Pnkp F21D5.5 CG9601 At3g14890 TPP1 TPP1
Base Excision Repair (BER) SMUG1 Smug1 CG5285
Base Excision Repair (BER) TDG Tdg Thd1 thp1
Base Excision Repair (BER) UNG Ung Y56A3A.29 AT3G18630 UNG1 ung1
Base Excision Repair (BER) XRCC1 Xrcc1 F55A3.1 XRCC1 XRCC1
Chromatin Structure CHAF1A (CAF1) Chaf1a T06D10.2 Caf1-180
Chromatin Structure H2AFX (H2AX) H2afx C50F4.13 CG31618 HTA10 HTA1 H2A
Conserved DNA damage response ATR Atr T06E4.3a mei-41 ATRAD3 MEC1 rad3
Conserved DNA damage response ATRIP (TREX1) 6620401K05Rik LCD1 (DD2) rad26
Conserved DNA damage response CHEK1 Chek1 Y39H10A.7a grp AT5G21326 CHK1 chk1 (rad27)
Conserved DNA damage response CHEK2 Chek2 T08D2.7 lok RAD53 cds1
Conserved DNA damage response HUS1 Hus1 H26D21.1 Hus1-like AT1G52530 MEC3 hus1
Conserved DNA damage response RAD1 Rad1 Y41C4A.14 Rad1 AT4G17760 RAD17 rad1
Conserved DNA damage response RAD17 (RAD24) Rad17 F32A11.2 Rad17 ATRAD17 RAD24 rad17
Conserved DNA damage response RAD9A Rad9 Y39A1A.23 Rad9 DDC1 rad9
Conserved DNA damage response RRM1 Rrm1 T23G5.1 RnrL RNR1 RNR1
RNR3

cdc22
Conserved DNA damage response RRM2 Rrm2 C03C10.3 RnrS TSO2 RNR2 suc22
Conserved DNA damage response RRM2B Rrm2b C03C10.3 RnrS TSO2 RNR2 suc22
Conserved DNA damage response TP53 Trp53 F52B5.5 p53
Direct Reversal of Damage DEPC-1 (ABH3) 1810020C19Rik
Direct Reversal of Damage MGC90512 (ABH2) AU016977
Direct Reversal of Damage MGMT Mgmt agt MGT1 SPAC1250.04c
DNA polymerases MAD2L2 (REV7) Mad2l2 Y69A2AR.30a rev7 REV7 MAD2 SPAC12D12.09
DNA polymerases PCNA pcna W03D2.4 mus209 PCNA2 POL30 pcn1
DNA polymerases POLA Pola Y47D3A.29 ICU2 pol1p pol1
DNA polymerases POLB Polb POL4
DNA polymerases POLD1 Pold1 F10C2.4 Dpol-d EMB2780 CDC2 cdc6
DNA polymerases POLE Pole F33H2.5 Dpol-e POL2A POL2 cdc20
DNA polymerases POLG Polg Y57A10A.15 tam MIP1 SPCC24B10.22
DNA polymerases POLH Polh F53A3.2 Dpol-n UMUC RAD30 eso1
DNA polymerases POLI (RAD30B) Poli Dpol-i RAD30 eso1
DNA polymerases POLK (DINB1) Polk F22B7.6 AT1G49980
DNA polymerases POLL Poll POLL POL4 SPAC2F7.06c
DNA polymerases POLM Polm
DNA polymerases POLN (POL4P) Poln
DNA polymerases POLQ Polq W03A3.2 mus308 AT4G32700 BRR2
DNA polymerases POLS Pols ZK858.1 CG11265 AT5G53770 TRF4 cid14
DNA polymerases REV1L (REV1) Rev1l ZK675.2 Rev1 REV1 REV1 SPBC1347.01c
DNA polymerases REV3L (POLZ) Rev3l Y37B11A.2 mus205 ATREV3 REV3 rev3
Editing and processing nucleases EXO1 (HEX1) Exo1 F45G2.3 tos AT1G29630 EXO1 exo1
Editing and processing nucleases FEN1 (Dnase IV) Fen1 Y47G6A.8 Fen1 AT5G2668 RAD27 rad2
Editing and processing nucleases FLJ35220 (ENDOV) A730011L01Rik C08H9.3a AT4G31150 SPAC1F12.06c
Editing and processing nucleases SPO11 Spo11 T05E11.4 mei-W68 RHL2 SPO11
Editing and processing nucleases TREX 1 (Dnase III) TrexI
Editing and processing nucleases TREX2 Trex2 CG3165
Fanconi anemia FANCA Fanca
Fanconi anemia FANCAE Fance
Fanconi anemia FANCB Fancab
Fanconi anemia FANCC Fancc
Fanconi anemia FANCD2 Fancd2 Fancd2 AT4G14970
Fanconi anemia FANCF Fancf
Fanconi anemia FANCG (XRCC9) Fancg
Fanconi anemia FANCI Facni W02D3.10a CG13745 AT5G49110
Fanconi anemia FANCL Fancl CG12812 AT5G65740
Fanconi anemia FANCM Fancm CG7922 DEAD/DEADH DEADH Mfh1
Genes defective in diseases ATM Atm Y48G1BL.2 tefu ATM TEL1 tel1
Genes defective in diseases BLM Blm T04A11.6 mus309 ATRECQ4A/ATSGS1 SGS1 rqh1
Genes defective in diseases RECQL4 Recql4 F18C5.2 RecQ4 AT1G27880 SGS1
Genes defective in diseases WRN Wrn F18C5.2 CG7670 SGS1
Homologous Recombination BRCA1 Brca1 C36A4.8 CG32580 ATBARD1/BARD1 RAD18
Homologous Recombination BRCA2 Brca2 BRCA2B
Homologous Recombination DMC1 Dmc1h Y43C5A.6a spn-A ATDMC1 DMC1 dmc1
Homologous Recombination EME1 (MMS4L) Eme1 F56A6.4 CG12936 MMS4 eme1
Homologous Recombination GEN1 Gen1 FBgn0027914 AT1G01880 YEN1
Homologous Recombination MRE11A Mre11a C29A12.4 mre11 MRE11 rad32
Homologous Recombination MUS81 Mus81 C43E11.2a mus81 MRE11 MUS81 mus81
Homologous Recombination NBS1 Nbn B0041.7 nbs ATMUS81 XRS2 nbs1
Homologous Recombination RAD21 Rad21 F10G7.4 Rad21 MCD1 SPCC338.17c
Homologous Recombination RAD50 Rad50 T04H1.4 rad50 RAD50 rad50
Homologous Recombination RAD51 Rad51 Y43C5A.6a spn-A RAD50 RAD51 rhp51
Homologous Recombination RAD51C Rad51c Y43C5A.6a spn-D ATRAD51C DMC1
Homologous Recombination RAD51L1 (RAD51B) Rad51l1 Y43C5A.6a spn-A ATRAD51B/RAD51B RAD51
Homologous Recombination RAD51L3 (RAD51D) Rad51l3 Y43C5A.6a Rad51C DMC1
Homologous Recombination RAD52 Rad52 RAD52 rad22
Homologous Recombination RAD54B Rad54B W06D4.6 okra RDH54 rdh54
Homologous Recombination RAD54L Rad54l W06D4.6 okra ATRAD54/CHR25 RAD54 rhp54
Homologous Recombination SHFM1 (DSS1) Shfdg1 Y119D3B.15 ATDSS1 DSS1 dss1
Homologous Recombination SMC6L1 Smc6l1 C23H4.6 CG5524 SMC RHC18 smc6
Homologous Recombination XRCC2 Xrcc2 Y43C5A.6a spn-D XRCC3 RAD51
Homologous Recombination XRCC3 Xrcc3 Y43C5A.6a spn-B XRCC3 DMC1 rhp57
Mismatch Excision repair (MMR) MLH1 Mlh1 T28A8.7 Mlh1 ATMLH1 MLH1 mlh1
Mismatch Excision repair (MMR) MLH3 Mlh3 T28A8.7 Pms2 ATMLH3/MLH3 MLH3
Mismatch Excision repair (MMR) MSH2 Msh2 H26D21.2 spel1 MSH2 MSH2 swi8
Mismatch Excision repair (MMR) MSH3 Msh3 Y47G6A.11 spel1 MSH3 MSH3 swi4
Mismatch Excision repair (MMR) MSH4 Msh4 ZK1127.11 spel1 MSH4 MSH4
Mismatch Excision repair (MMR) MSH5 Msh5 F09E8.3 spel1 AT3G20475 MSH5
Mismatch Excision repair (MMR) MSH6 Msh6 Y47G6A.11 CG7003 MSH6 MSH6 muts
Mismatch Excision repair (MMR) PMS1 MGC36491 H12C20.2a Pms2 PMS1 pms1
Mismatch Excision repair (MMR) PMS2 Pms2 H12C20.2a Pms2 AT4G02460 PMS1 mlh1
Mismatch Excision repair (MMR) PMS2L3 Pms2 H12C20.2a Pms2 PMS1
Mismatch Excision repair (MMR) PMS2L4 (PMS6) Pms2 H12C20.2a Pms2 AT4G02460 PMS1 pms1
Modulation of nucleotide pools DUT Dut K07A1.2 dUTPase AT3G46940 DUT1
Modulation of nucleotide pools NUDT1 (MTH1) Nudt1
Modulation of nucleotide pools RRM2B (p52R2) Rrm2b C03C10.3 RnrS TSO2 RNR2
NER related CKN1 (ERCC8) Ercc8 K07A1.12 wds ATCSA-1 RAD28 ercc8
NER related DDB1 Ddb1 M18.5 DDB1 ddb1
NER related DDB2 Ddb2 C18E3.5 CG5543 DDB2 PRP4
NER related ERCC6 (CSB) ERCC6 F53H4.1 Hel89B CHR8 RAD26 rhp26
NER related MMS19L (MMS19) Mms19l C24G6.3 Mms19 AT5G48120 MET18
NER related TFF2 Tff2 T23H2.3a RAD16
NER related XAB2 (HCNP) Xab2 C50F2.3 CG6197 AT5G28740 SYF1
Non-homologous end-joining DCLRE1C (Artemis) Dclre1c Snm1
Non-homologous end-joining DNA-PK DNA-PK
Non-homologous end-joining LIG4 Lig4 C07H6.1 Lig4 ATLIG4 DNL4 lig4
Non-homologous end-joining PRKDC Prkdc B0261.2a Tor TOR1 tor1
Non-homologous end-joining SIRT1 Sirt1 R11A8.4 Sir2 ILR1 SIR2 sir2
Non-homologous end-joining XRCC4 Xrcc4 XRCC4
Non-homologous end-joining XRCC5 (Ku80) Xrcc5 R07E5.8 Ku80 ATKU80/KU80 YKU80 pku80
Non-homologous end-joining XRCC6 (Ku70) Xrcc6 Y47D3A.4 Irbp ATKU70/KU70 YKU70 pku70
Nucleotide Excision Repair (NER) CCNH Ccnh Y49F6B.1 CycH CYCH1 CCL1
Nucleotide Excision Repair (NER) CDK7 Cdk7 Y39G10AL.3 Cdk7 AT/CDKD1/CAK3AT KIN28
Nucleotide Excision Repair (NER) CETN2 Cetn2 T21H3.3 CG17493 CDC31
Nucleotide Excision Repair (NER) ERCC1 Ercc1 F10G8.7 Ercc1 ERCC1 RAD10 swi10
Nucleotide Excision Repair (NER) ERCC2 (XPD) Ercc2 Y50D7A.2 Xpd ATXPD/UVH6 RAD3 rad15
Nucleotide Excision Repair (NER) ERCC3 (XPB) Ercc3 Y66D12A.15 hay XPB2 SSL2 ercc3sp
Nucleotide Excision Repair (NER) ERCC4 (XPF) Ercc4 C47D12.8 mei-9 RAD1 rad16
Nucleotide Excision Repair (NER) ERCC5 (XPG) Ercc5 F57B10.6 mus201 UVH3 RAD2 rad13
Nucleotide Excision Repair (NER) FBL3 (FBXL2) Fbxl2 C02F5.7b CG9003 RAD7
Nucleotide Excision Repair (NER) GTF2H1 Gtf2h1 R02D3.3 Tfb1 AT1G55750 TFB1 tfb1
Nucleotide Excision Repair (NER) GTF2H2 Gtf2h2 T16H12.4 Ssl1 ATGTF2H2/GTF2H2 SSL1 ssl1
Nucleotide Excision Repair (NER) GTF2H3 D5Ertd679e ZK1128.4 Tfb4 AT1G18340 TFB4 tfb4
Nucleotide Excision Repair (NER) GTF2H4 Gtf2h4 Y73F8A.24 Tfb2 TFB2 tfb2
Nucleotide Excision Repair (NER) GTF2H5 (TTDA) D17Wsu155e Y55B1AL.2 CG31917 AT1G12400 TFB5 tfb5
Nucleotide Excision Repair (NER) LIG1 Lig1 C29A12.3a CG5602 AT1G49250 CDC9 cdc17
Nucleotide Excision Repair (NER) MT1 Mt1 F53G2.7 Mat1 AT4G30820 TFB3 pmh1
Nucleotide Excision Repair (NER) RAD23A (HR23A) Rad23a ZK20.3 Rad23 RAD23
Nucleotide Excision Repair (NER) RAD23B (HR23B) Rad23b ZK20.3 Rad23 RAD23 rhp23
Nucleotide Excision Repair (NER) RPA1 Rpa1 F18A1.5 RpA-70 AT4G19130 RFA1 ssb1
Nucleotide Excision Repair (NER) RPA2 Rpa2 M04F3.1 CG9273 ATRPA2/ROR1/RPA RFA2 ssb2
Nucleotide Excision Repair (NER) RPA3 Rpa3 CG15220 ssb3
Nucleotide Excision Repair (NER) XPA Xpa K07G5.2 Xpac RAD14 rhp14
Nucleotide Excision Repair (NER) XPC Xpc Y76B12C.2 mus210 RAD4-like RAD4 rhp41
Other suspected genes APTX (aprataxin) Aptx C26F1.7 CG5316 HNT3 SPCC18.09c
Other suspected genes DCLRE1A (SNM1) Dclre1a F39H2.5 Snm1 PSO2
Other suspected genes DCLRE1B (SNM1B) Dclre1b F39H2.5 Snm1 AT1G27410 PSO2
Other suspected genes HEL308 Hel308 Y55B1AL.3a mus301 HFM1
Other suspected genes RAD52B (RDM1) Rad52b
Other suspected genes RECQL (RECQ1) Recql K02F3.12a mus309 RECQL2 SGS1 Ste13
Other suspected genes RECQL5 Recql5 E03A3.2 RecQ5 RecQl3 SGS1
Other suspected genes RPA4 Rpa2 CG9273 AT3G02920 RFA2
Rad6 pathway RAD18 Rad18 T02C1.1 l373Ah RAD18 rhp18
Rad6 pathway UBE2A (RAD6A) Ube2a C35B1.1 UbcD6 ATUBC2 RAD6 rhp6
Rad6 pathway UBE2B (RAD6B) Ube2b C35B1.1 UbcD6 UBC1 RAD6 rhp6
Rad6 pathway UBE2N (UBC13) Ube2n Y54G2A.31 ben UBC13B/UBC36 UBC13 ubc13
Rad6 pathway UBE2V2 (MMS2) Ube2v2 F39B2.2 Uev1A MMZ1/UEV1A MMS2 mms2
Repair of DNA-protein crosslinks TDP1 Tdp1 F52C12.1 Tdp1 AT5G15170 TDP1 tdp1